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Calphostin C
CAS No. 121263-19-2
Calphostin C( UCN 1028C | PKF115-584 )
Catalog No. M10793 CAS No. 121263-19-2
A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCalphostin C
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM.
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DescriptionA potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM; displays >1,000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase; inhibits cell growth and promotes apoptosis in HeLa S3 and MCF-7 cells with IC50 of 0.23 and 0.18 uM, respectively; also inhibits phospholipase D1 and D2 (IC50=100 nM); also blocks β-catenin/Tcf transcriptional activity.Solid Tumors Discontinued.
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In Vitro——
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In Vivo——
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SynonymsUCN 1028C | PKF115-584
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number121263-19-2
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Formula Weight790.76
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Molecular FormulaC44H38O14
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(CC1=C2C3=C(C(=C(C4=C3C(=C5C2=C(C(=O)C=C5OC)C(=C1OC)O)C(=CC4=O)OC)O)OC)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC(=O)C7=CC=CC=C7
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Chemical Name1-(4,9-dihydroxy-12-(2-(((4-hydroxyphenoxy)carbonyl)oxy)propyl)-2,6,7,11-tetramethoxy-3,10-dioxo-3,10-dihydroperylen-1-yl)propan-2-yl benzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sukhdeo K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21.
2. Kobayashi E, et al. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4.
3. Sciorra VA, et al. Biochemistry. 2001 Feb 27;40(8):2640-6.
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